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Kornstein told Contemporary OB/GYN. Concern arose because flibanserin is a minor 5-HT2C receptor antagonist, and “the 5-HT2C agonist lorcaserin has been approved by the FDA as a weight loss drug,” Dr. Kornstein says. “Thus, one might have expected flibanserin to cause weight gain rather than weight loss. This suggests that the observed weight loss in this analysis is unlikely to be caused by the serotonin-related activity of flibanserin.” For the five studies combined, the mean weight at baseline was about 73 kg (161 lbs). “A weight loss of at least 5% of baseline body weight at 24 weeks would be a weight loss of at least 3.6 kg (8 lbs), which occurred in 21% of the women on flibanserin versus 7.8% of those on placebo,” Dr. Kornstein says. These findings are in contrast to trials of FDA-approved weight-loss medications, where the average weight loss has been 5 kg to 10 kg for the active drug versus 1 kg to 3 kg for placebo, according to Dr.
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